Page 46 - 2021 White Paper
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1 White Paper on the Business Environment in China
main directions taken to work out a vaccine for towards vaccine candidates. At least 24 Covid-19
Covid-19. Such a variety of possibilities increased candidate vaccines were in clinical evaluation
the odds of finding the right way to the desired mid-summer 2020, and another 142 were in
result, according to Zimhony. "The major game- preclinical evaluation. Chinese experts said in a
changer to overcome this pandemic is vaccine study published in medical journal The Lancet that
development," Zimhony said, who believes that a phase 2 trial of a Covid-19 vaccine candidate
the first clinical implications of the intense vaccine has found that the vaccine is safe and induces
research will be available in six months. Gili Regev- an immune response. "The phase 2 trial adds
Yochay, director of the infection prevention further evidence on safety and immunogenicity
control unit at Sheba Medical Center, believes that in a large population than the phase 1 trial. This
only a vaccine could stop the global outbreak of is an important step in evaluating this early-stage
the novel coronavirus. "It seems there is no proper experimental vaccine and phase 3 trials are now
treatment for Covid-19 disease patients, and the u n d e r way," s a i d Pro fe s s o r Fe n g c a i Z h u f ro m
only effec tive global cure would be a vaccine," Jiangsu Provincial Center for Disease Control and
she noted. The biggest challenge in the work, Prevention, China. A report published also in The
according to Regev-Yochay, is to find a completely Lancet revealed the results of the phase 1/2 trial of
safe vaccine for everybody and a reliable way the Oxford coronavirus vaccine ChAdOx1 nCoV-19.
to deliver it to all kinds of people with different It indicates no early safety concerns and produces
health situations. "We need to be very cautious strong immune response. The Russian Defense
with vaccines. It's much more complicated than Ministry said that together with the Gamaleya
clinical tr ials with the drugs," stressed R egev- Scientific Research Institute of Epidemiology and
Yochay. Many Covid-19 patients don't have Microbiology, it has successfully completed clinical
symptoms or have mild ones, "so we need to make trials of Covid-19 vaccine with the participation
sure we don't inject them with vaccines, drugs, or of volunteers. "Without exception, all volunteers,
chemicals that could do more harm than good," having received immunity from the coronavirus, felt
she said. International sharing of information fine," First Deputy Defense Minister of the Russian
could help researchers compare the effectiveness Federation Ruslan Khadzhismelovich Tsaikov told
of different vaccines and speed up the progress Moscow's Argumenty i Fakty newspaper. German
of the development. According to the statistics of biotech company BioNTech and US pharmaceutical
the World Health Organization, currently more corporation Pfizer announced that data from their
than 130 Covid-19 candidate vaccines are being experimental Covid-19 vaccine showed that it was
developed worldwide, with about 10 of them safe, and induced an immune response and high-
being already in clinical evaluation. Among the level T-cell responses against the novel coronavirus
vaccine challenges is also its mass production for in patients. Research institutes in other countries
the use of all of humanity, which calls for global also reported progress in their Covid-19 vaccine
cooperation. "We need to vaccinate billions of trials. Despite the good news on Covid-19
people around the globe. Better to do it before candidate vaccines, experts warned of uncertainties
the upcoming winter to prevent the dangerous of vaccine development and clinical trials, as
effect of dual infection of influenza and COVID-19," well as multiple risks and challenges including
said Zimhony. Ben-Yehuda said she believes new virus mutation, while appealing for an objective,
technologies of computational medicine and rational and scientific attitude towards vaccine
international sharing of big data could help create research. Dr. Michael Ryan, executive director of
personalized medicine for Covid-19 infection, the WHO Health Emergencies Program, said that
as the virus affects people differently (Xinhua, there is no accurate timetable for the delivery of
Development Requires). Covid-19 vaccines. Although the preliminary data
of some candidate vaccines is quite promising, it
By July, many countries started reported is still unpredictable which one is totally clinically
development in their Covid-19 vaccine trials, effective. While a vaccine candidate might show
bringing hope to the world amid the still raging its effectiveness by year's end, the question is how
pandemic, while health experts called for soon it could be mass produced, he added. Saudi
an objective, rational and scientific attitude Arabia's Asharq al-Awsat newspaper said recently
46
main directions taken to work out a vaccine for towards vaccine candidates. At least 24 Covid-19
Covid-19. Such a variety of possibilities increased candidate vaccines were in clinical evaluation
the odds of finding the right way to the desired mid-summer 2020, and another 142 were in
result, according to Zimhony. "The major game- preclinical evaluation. Chinese experts said in a
changer to overcome this pandemic is vaccine study published in medical journal The Lancet that
development," Zimhony said, who believes that a phase 2 trial of a Covid-19 vaccine candidate
the first clinical implications of the intense vaccine has found that the vaccine is safe and induces
research will be available in six months. Gili Regev- an immune response. "The phase 2 trial adds
Yochay, director of the infection prevention further evidence on safety and immunogenicity
control unit at Sheba Medical Center, believes that in a large population than the phase 1 trial. This
only a vaccine could stop the global outbreak of is an important step in evaluating this early-stage
the novel coronavirus. "It seems there is no proper experimental vaccine and phase 3 trials are now
treatment for Covid-19 disease patients, and the u n d e r way," s a i d Pro fe s s o r Fe n g c a i Z h u f ro m
only effec tive global cure would be a vaccine," Jiangsu Provincial Center for Disease Control and
she noted. The biggest challenge in the work, Prevention, China. A report published also in The
according to Regev-Yochay, is to find a completely Lancet revealed the results of the phase 1/2 trial of
safe vaccine for everybody and a reliable way the Oxford coronavirus vaccine ChAdOx1 nCoV-19.
to deliver it to all kinds of people with different It indicates no early safety concerns and produces
health situations. "We need to be very cautious strong immune response. The Russian Defense
with vaccines. It's much more complicated than Ministry said that together with the Gamaleya
clinical tr ials with the drugs," stressed R egev- Scientific Research Institute of Epidemiology and
Yochay. Many Covid-19 patients don't have Microbiology, it has successfully completed clinical
symptoms or have mild ones, "so we need to make trials of Covid-19 vaccine with the participation
sure we don't inject them with vaccines, drugs, or of volunteers. "Without exception, all volunteers,
chemicals that could do more harm than good," having received immunity from the coronavirus, felt
she said. International sharing of information fine," First Deputy Defense Minister of the Russian
could help researchers compare the effectiveness Federation Ruslan Khadzhismelovich Tsaikov told
of different vaccines and speed up the progress Moscow's Argumenty i Fakty newspaper. German
of the development. According to the statistics of biotech company BioNTech and US pharmaceutical
the World Health Organization, currently more corporation Pfizer announced that data from their
than 130 Covid-19 candidate vaccines are being experimental Covid-19 vaccine showed that it was
developed worldwide, with about 10 of them safe, and induced an immune response and high-
being already in clinical evaluation. Among the level T-cell responses against the novel coronavirus
vaccine challenges is also its mass production for in patients. Research institutes in other countries
the use of all of humanity, which calls for global also reported progress in their Covid-19 vaccine
cooperation. "We need to vaccinate billions of trials. Despite the good news on Covid-19
people around the globe. Better to do it before candidate vaccines, experts warned of uncertainties
the upcoming winter to prevent the dangerous of vaccine development and clinical trials, as
effect of dual infection of influenza and COVID-19," well as multiple risks and challenges including
said Zimhony. Ben-Yehuda said she believes new virus mutation, while appealing for an objective,
technologies of computational medicine and rational and scientific attitude towards vaccine
international sharing of big data could help create research. Dr. Michael Ryan, executive director of
personalized medicine for Covid-19 infection, the WHO Health Emergencies Program, said that
as the virus affects people differently (Xinhua, there is no accurate timetable for the delivery of
Development Requires). Covid-19 vaccines. Although the preliminary data
of some candidate vaccines is quite promising, it
By July, many countries started reported is still unpredictable which one is totally clinically
development in their Covid-19 vaccine trials, effective. While a vaccine candidate might show
bringing hope to the world amid the still raging its effectiveness by year's end, the question is how
pandemic, while health experts called for soon it could be mass produced, he added. Saudi
an objective, rational and scientific attitude Arabia's Asharq al-Awsat newspaper said recently
46
